Acquired RhD mosaicism identifies fibrotic transformation of thrombopoietin receptor-mutated essential thrombocythemia
نویسندگان
چکیده
منابع مشابه
Myelomegakaryoblastic transformation of essential thrombocythemia.
Essential thrombocytherrlia, considered one of the least common of the myeloproliferative disorders, is being diag nosed more frequently with the increasing use of automated blood cell counters. Essential thrombocythemia described by Epstein and Goendel in 1934 is a diagnosis of exclusion i.e., exclusion of all sy stemic conditions associated with thrombocytosis in an individual with a persiste...
متن کاملPresence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.
Mutations in signaling molecules of the cytokine receptor axis play a central role in myeloproliferative neoplasm (MPN) pathogenesis. Polycythemia vera is mainly related to JAK2 mutations, whereas a wider mutational spectrum is detected in essential thrombocythemia (ET) with mutations in JAK2, the thrombopoietin (TPO) receptor (MPL), and the calreticulin (CALR) genes. Here, we studied the mutat...
متن کاملCalreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thrombotic event as compared to patients with a JAK2 mutation. We report a case of CALR-mutated ET wh...
متن کاملAcute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies of coexisting JAK2 V617F-positive myeloproliferative neoplasms and mature B cell malignancies indicate distinct disease entities arising in myeloid and lymphoid committed he...
متن کاملBlast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors
Polycythemia vera (PV) and essential thrombocythemia (ET) constitute two of the three BCR-ABL1-negative myeloproliferative neoplasms and are characterized by relatively long median survivals (approximately 14 and 20 years, respectively). Potentially fatal disease complications in PV and ET include disease transformation into myelofibrosis (MF) or acute myeloid leukemia (AML). The range of repor...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2017
ISSN: 0041-1132
DOI: 10.1111/trf.14201